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Zhuo Chen Selected Research

PDK1 inhibitor 9za

1/2020A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells.

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Zhuo Chen Research Topics

Disease

147Neoplasms (Cancer)
12/2022 - 01/2003
29Infections
06/2022 - 03/2012
25Neoplasm Metastasis (Metastasis)
01/2022 - 10/2002
23Inflammation (Inflammations)
10/2022 - 04/2006
21Breast Neoplasms (Breast Cancer)
05/2022 - 09/2007
12Obesity
10/2021 - 01/2011
10Neuroinflammatory Diseases
03/2022 - 01/2017
10Glioblastoma (Glioblastoma Multiforme)
10/2020 - 01/2014
9Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 04/2016
8Type 2 Diabetes Mellitus (MODY)
01/2022 - 07/2009
8Hepatocellular Carcinoma (Hepatoma)
08/2018 - 11/2009
7Lung Neoplasms (Lung Cancer)
07/2022 - 07/2012
7Squamous Cell Carcinoma of Head and Neck
01/2022 - 03/2004
7Hypertension (High Blood Pressure)
01/2022 - 01/2015
7Fibrosis (Cirrhosis)
01/2022 - 12/2014
7Alzheimer Disease (Alzheimer's Disease)
02/2021 - 10/2010
7Body Weight (Weight, Body)
01/2021 - 06/2004
7Carcinogenesis
01/2021 - 07/2014
7Atherosclerosis
08/2019 - 01/2014
6COVID-19
06/2022 - 04/2020
6Wounds and Injuries (Trauma)
04/2022 - 01/2007
6Parkinson Disease (Parkinson's Disease)
03/2022 - 01/2019
6Hemorrhage
12/2021 - 06/2010
6Carcinoma (Carcinomatosis)
11/2020 - 01/2012
6Glioma (Gliomas)
01/2020 - 01/2014
6Prostatic Neoplasms (Prostate Cancer)
01/2019 - 12/2012
6Nasopharyngeal Carcinoma
07/2017 - 11/2014
5Autoimmune Diseases (Autoimmune Disease)
10/2022 - 11/2008
5Pain (Aches)
01/2022 - 06/2010
5Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2022 - 03/2014
5Insulin Resistance
03/2021 - 06/2014
5Brain Ischemia (Cerebral Ischemia)
09/2019 - 05/2018
4Virus Diseases (Viral Diseases)
06/2022 - 06/2013
4Colorectal Neoplasms (Colorectal Cancer)
05/2022 - 01/2016
4Heart Failure
01/2022 - 11/2017
4Adenocarcinoma of Lung
01/2022 - 11/2014
4Hyperglycemia
11/2021 - 01/2016
4Diabetic Nephropathies (Diabetic Nephropathy)
10/2021 - 09/2016
4Thrombosis (Thrombus)
01/2021 - 01/2017
4Adenocarcinoma
01/2020 - 01/2011
4Hypoxia (Hypoxemia)
01/2019 - 01/2013
4Leukemia
08/2018 - 11/2013
4Stomach Neoplasms (Stomach Cancer)
08/2018 - 08/2016
4Disease Resistance
01/2017 - 03/2008
4Lymphatic Metastasis
11/2016 - 01/2003
3Ganglion Cysts (Ganglion)
01/2022 - 01/2021
3Brain Injuries (Brain Injury)
01/2022 - 05/2018

Drug/Important Bio-Agent (IBA)

42Proteins (Proteins, Gene)FDA Link
06/2022 - 10/2002
33Pharmaceutical PreparationsIBA
12/2022 - 04/2009
22Biomarkers (Surrogate Marker)IBA
08/2022 - 11/2008
19MicroRNAs (MicroRNA)IBA
01/2022 - 09/2010
15Biological ProductsIBA
05/2022 - 04/2015
13Glucose (Dextrose)FDA LinkGeneric
01/2022 - 07/2009
12Photosensitizing Agents (Photosensitizers)IBA
07/2020 - 06/2010
11Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
01/2020 - 12/2009
111-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2020 - 06/2010
10Messenger RNA (mRNA)IBA
05/2021 - 10/2002
9Long Noncoding RNAIBA
01/2022 - 12/2014
8TeaIBA
04/2022 - 01/2016
8Therapeutic UsesIBA
01/2021 - 06/2008
8Urokinase Plasminogen Activator ReceptorsIBA
01/2019 - 10/2002
7CytokinesIBA
02/2022 - 04/2006
7Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 01/2015
7LipopolysaccharidesIBA
08/2021 - 01/2017
7ErbB Receptors (EGF Receptor)IBA
01/2017 - 09/2004
6Peptides (Polypeptides)IBA
10/2021 - 01/2009
6RNA (Ribonucleic Acid)IBA
05/2021 - 09/2010
6EnzymesIBA
01/2021 - 11/2011
6Indicators and Reagents (Reagents)IBA
01/2021 - 09/2015
6DNA (Deoxyribonucleic Acid)IBA
01/2020 - 05/2009
5Interleukin-6 (Interleukin 6)IBA
01/2022 - 12/2018
5LipidsIBA
01/2022 - 02/2011
5Oxygen (Dioxygen)IBA
01/2022 - 06/2015
5Antiviral Agents (Antivirals)IBA
01/2022 - 10/2017
5Cisplatin (Platino)FDA LinkGeneric
11/2020 - 11/2017
4Glycoproteins (Glycoprotein)IBA
06/2022 - 06/2013
4Circular RNAIBA
02/2022 - 01/2020
4CholesterolIBA
01/2022 - 07/2010
4CollagenIBA
12/2021 - 04/2005
4LigandsIBA
08/2021 - 03/2004
4NanodiamondsIBA
10/2020 - 10/2018
4Plasminogen Activator Inhibitor 1IBA
04/2020 - 01/2017
4AntibodiesIBA
01/2020 - 01/2009
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 01/2013
4Folic Acid (Vitamin M)FDA LinkGeneric
01/2019 - 04/2009
4Zn(II)-phthalocyanine (zinc phthalocyanine)IBA
10/2018 - 01/2012
4Gefitinib (Iressa)FDA Link
11/2016 - 05/2007
3Agammaglobulinaemia Tyrosine KinaseIBA
10/2022 - 01/2022
3AutoantibodiesIBA
02/2022 - 11/2008
3Adenosine Triphosphate (ATP)IBA
01/2022 - 01/2011
3Protein Kinases (Protein Kinase)IBA
01/2022 - 01/2021
3Hematoxylin (Haematoxylon)IBA
01/2022 - 05/2018

Therapy/Procedure

51Therapeutics
01/2022 - 05/2007
18Drug Therapy (Chemotherapy)
01/2022 - 01/2014
12Photochemotherapy (Photodynamic Therapy)
01/2021 - 06/2010
8Radiotherapy
08/2021 - 06/2014
6Lasers (Laser)
09/2020 - 03/2006
5Immunotherapy
01/2021 - 01/2018
5Precision Medicine
01/2020 - 04/2015
4Transplantation
01/2022 - 04/2005